CAMPTOTHECIN AND KHAT (CATHA EDULIS FORSK.) INDUCED DISTINCT CELL DEATH PHENOTYPES INVOLVING MODULATION OF C-FLIPL, MCL-1, PROCASPASE-8 AND MITOCHONDRIAL FUNCTION IN ACUTE MYELOID LEUKEMIA CELL LINES

Abstract Background An organic extract of the recreational herb khat (Catha edulis Forsk.) triggers cell death in various leukemia cell lines in vitro.The chemotherapeutics camptothecin, a plant alkaloid topoisomerase I inhibitor, was tested side-by-side with khat in a panel of acute myeloid leukemia cell lines to elucidate mechanisms of toxicity.R

If a turbine loses its electrical load, it will rotate freely and increase speed, eventually achieving that rotational speed which produces zero net torque.This is known as a runaway situation.Unlike many other types of turbine, a marine current turbine will typically overshoot the final runaway speed before slowing down and settling at the runaway

With the advancement of artificial intelligence, deep learning has become instrumental in land cover classification.While there has been a notable emphasis on refining model structures to improve classification accuracy, it is imperative to also emphasize the pivotal role of data-driven optimization techniques.This paper presents an in-depth invest